Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson’s Disease
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson’s Disease
Auteurs : Xiaojuan Dan [République populaire de Chine] ; Bradley R. King [Canada] ; Julien Doyon [Canada] ; Piu Chan [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Female, Functional Laterality (physiology), Hand, Humans, Learning (physiology), Male, Memory Consolidation (physiology), Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Psychomotor Performance (physiology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Functional Laterality, Learning, Memory Consolidation, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Case-Control Studies, Female, Hand, Humans, Male, Middle Aged.
Abstract
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson’s disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.
Url:
DOI: 10.1371/journal.pone.0134291
PubMed: 26222151
PubMed Central: 4519305
Affiliations:
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Le document en format XML
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King</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Functional Neuroimaging Unit, Department of Psychology, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson’s Disease, Xuanwu Hospital of Capital Medical University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson’s Disease, Xuanwu Hospital of Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hand</term><term>Humans</term><term>Learning (physiology)</term><term>Male</term><term>Memory Consolidation (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Psychomotor Performance (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Learning</term><term>Memory Consolidation</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Hand</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson’s disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Karni, A" uniqKey="Karni A">A Karni</name></author><author><name sortKey="Meyer, G" uniqKey="Meyer G">G Meyer</name></author><author><name sortKey="Jezzard, P" uniqKey="Jezzard P">P Jezzard</name></author><author><name sortKey="Adams, Mm" uniqKey="Adams M">MM Adams</name></author><author><name sortKey="Turner, R" uniqKey="Turner R">R Turner</name></author><author><name sortKey="Ungerleider, Lg" uniqKey="Ungerleider L">LG Ungerleider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karni, A" uniqKey="Karni A">A Karni</name></author><author><name sortKey="Meyer, G" uniqKey="Meyer G">G Meyer</name></author><author><name sortKey="Rey Hipolito, C" uniqKey="Rey Hipolito C">C Rey-Hipolito</name></author><author><name sortKey="Jezzard, P" 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Garnett</name></author><author><name sortKey="Firnau, G" uniqKey="Firnau G">G Firnau</name></author><author><name sortKey="Lang, A" uniqKey="Lang A">A Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penhune, Vb" uniqKey="Penhune V">VB Penhune</name></author><author><name sortKey="Doyon, J" uniqKey="Doyon J">J Doyon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author><author><name sortKey="Obeso, Ja" uniqKey="Obeso J">JA Obeso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, Br" uniqKey="King B">BR King</name></author><author><name sortKey="Fogel, Sm" uniqKey="Fogel S">SM Fogel</name></author><author><name sortKey="Albouy, G" uniqKey="Albouy G">G Albouy</name></author><author><name sortKey="Doyon, J" uniqKey="Doyon J">J Doyon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Jk" uniqKey="Wilson J">JK Wilson</name></author><author><name sortKey="Baran, B" uniqKey="Baran B">B Baran</name></author><author><name sortKey="Pace Schott, Ef" uniqKey="Pace Schott E">EF Pace-Schott</name></author><author><name sortKey="Ivry, Rb" uniqKey="Ivry R">RB Ivry</name></author><author><name sortKey="Spencer, Rmc" uniqKey="Spencer R">RMC Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spencer, Rmc" uniqKey="Spencer R">RMC Spencer</name></author><author><name sortKey="Gouw, Am" uniqKey="Gouw A">AM Gouw</name></author><author><name sortKey="Ivry, Rb" uniqKey="Ivry R">RB Ivry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Rm" uniqKey="Brown R">RM Brown</name></author><author><name sortKey="Robertson, Em" uniqKey="Robertson E">EM Robertson</name></author><author><name sortKey="Press, Dz" uniqKey="Press D">DZ Press</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Dan, Xiaojuan" sort="Dan, Xiaojuan" uniqKey="Dan X" first="Xiaojuan" last="Dan">Xiaojuan Dan</name></noRegion><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name><name sortKey="Chan, Piu" sort="Chan, Piu" uniqKey="Chan P" first="Piu" last="Chan">Piu Chan</name></country><country name="Canada"><noRegion><name sortKey="King, Bradley R" sort="King, Bradley R" uniqKey="King B" first="Bradley R." last="King">Bradley R. King</name></noRegion><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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